Magnetic Activated Cell Sorting (MACS): How It Works in Fertility Treatment

The MACS process involves the use of very small biodegradable magnetic particles. These particles have an antibody known as protein annexin. The antibody fastens itself to sperms with high DNA fragmentation, that are more likely to undergo apoptosis or programmed cell death. The semen sample is then passed through a column with weak magnetic fields around it. The apoptotic sperms get drawn towards the walls while the healthy ones pass through the channel.

Effects of MACS

Removing the unviable sperm from the semen sample increases the success rate of assisted reproductive techniques by selecting the best quality sperms. Studies show that it can increase the pregnancy rate by 10-15%. In the long run, this may also be lighter on the pocket as couples have a lower chance of requiring repeated cycles of IUI or IVF treatment.