Advanced ART techniques such as Magnetic Activated Cell Sorting (MACS) and DNA Fragmentation Index (DFI) testing are increasingly being used to solve cases of Male infertility.

Highlights:

• 67 men helped through the MACS technique
• 19 men helped with DFI testing
• Nova IVF Fertility has successfully achieved 25,000 clinical pregnancies through IVF

Infertility has been affecting approximately 15% of couples in their reproductive age, around the globe. Among the 60-80 million couples suffering from infertility, 15-20 million are in India alone. According to a study by World Health Organisation (WHO), male factor contributes to infertility in 51.2% of these cases.

Causes for male infertility

Male infertility is caused due to various medical, environmental and lifestyle factors that in turn affect the quality and quantity of sperm produced by men. Overexposure to certain environmental factors such as heat, toxins and chemicals has also proven to negatively affect the production of sperm in men. Industrial chemicals, heavy metals like lead, overheating of testicles by sitting for long hours, wearing tight clothing or working on a laptop computer for long stretches of time impair the production and functioning of sperms.

Discussing the causes of male infertility at a press meet held today, Dr Jasmine Kaur Dahiya, Fertility Consultant, Nova IVF Fertility, Jalandhar said, “Men facing sexual dysfunction like difficulty in ejaculation, reduced sexual desire or difficulty maintaining an erection should consult a fertility consultant and undergo proper tests to understand the condition. Pain, swelling or a lump in the testicle area, recurrent respiratory infections, abnormal breast growth, decreased facial or body hair or other signs of a chromosomal or hormonal abnormality also signs of male infertility and should be reported to fertility experts.”

Other factors that lead to poor quality sperms are the illicit use of drugs like anabolic steroids taken to stimulate muscle strength and growth, the use of cocaine or marijuana, and excessive consumption of alcohol and tobacco smoking. Stress and obesity also reduce fertility in men by impacting sperm quality and quantity.

Sperm DNA – a major cause to look out for:

Sperm DNA integrity is vital for successful fertilization, embryo development, pregnancy, and transmission of genetic material to the offspring. DNA fragmentation is the most frequent DNA anomaly present in the male gamete and is a term used to denote abnormal genetic material within the sperm which may lead to IVF failure and miscarriage. Detecting Sperm DNA fragmentation is not possible through a conventional semen analysis test. The process instead involves an advanced test which consists of the analysis of semen samples to calculate the percentage of sperms with DNA fragmentation. This is called DNA Fragmentation Index.

DFI testing helps detect men who are at risk of male infertility, manage male infertility and provide a prognostic value to evaluate the success of an IVF treatment cycle.

With poor quality sperms being one of the major causes of male infertility, modern technology allows fertility specialists to choose the best and the most healthy sperm for the process of ICSI (intra-cytoplasmic sperm injection), thereby increasing the chances of pregnancy.

Another such advanced ART technique that aids the success rates of IVF/ICSI is MACS (Magnetic Activated Cell Sorting).

Magnetic Activated Cell Sorting (MACS)

Magnetic Activated Cell Sorting is a semen preparation technique that involves the magnetic separation of healthy spermatozoa from the apoptotic ones, which have less fertility potential. The apoptosis (programmed cell death) is a regulation process of the cell cycle which may occur during spermatogenesis (the process of development of sperm cells or spermatozoa), thereby causing cell damages such as sperm DNA fragmentation. MACS helps isolate better sperms from the ones which are on the verge of death, and helps achieve better fertilisation rate, cleavage rate, implantation rate and pregnancy rate.

“MACS is one of the most effective sperm selection procedures that uses advance magnetic labelling for defective sperms. When the semen sample is passed through the isolated advance magnetic column, the bad/defective sperms are separated from the good/healthy sperms & these good sperms are later used for ICSI or Freezing. At Nova IVF Fertility, we implement the latest in MACS and DFI, to help provide a solution for male infertility cases” said Dr Jasmine.

MACS is known to be an effective method to treat male infertility and stands tall as a huge relief for many couples as well as fertility experts. Given the steady increase in the number of infertility cases reported in India, such advanced ART techniques come as a boon to several childless couples in the nation.

Nova IVF Fertility (NIF) is among the largest service providers in the fertility space and has successfully achieved over 25,000 clinical pregnancies through IVF.

About Nova IVF Fertility

Nova IVF Fertility (NIF) is India’s leading and fastest-growing chain of fertility and IVF centres and part of Asia Healthcare Holdings – the country’s only platform dedicated exclusively to single-speciality healthcare. With a legacy built on trust, transparency, and clinical excellence, Nova IVF Fertility has enabled over 96,000+ clinical pregnancies through its advanced reproductive technologies. With a footprint spanning 100+ centres across 60+ cities, Nova IVF Fertility is committed to making world-class fertility care accessible, personalised, and outcome-driven for couples across India.

Backed by a team of internationally trained embryologists and IVF specialists with over a decade of experience on average, NIF brings global best practices and ethical standards to the heart of India’s fertility landscape. The centres offer a full spectrum of fertility treatments, including medical management, basic Assisted Reproductive Technology (ART), and advanced ART procedures, all tailored to each couple’s unique journey.

For more information, please visit: https://www.novaivffertility.com/

Media contacts:

Debolina

Manager – PR, Nova IVF Fertility

Phone: +91 76194 62888

Email: debolina.mukherjee@novaivifertility.net

Using advance science and Assisted Reproductive Technology (ART) to help childless couples have successful IVF cycles

Highlights:

• Almost 50% of male infertility cases received at Nova IVF Fertility, Hisar has been helped through the MACS technique
• Nova IVF Fertility has successfully achieved 25,000 clinical pregnancies through IVF

Infertility is a condition where a couple is unable to conceive naturally despite having unprotected sex for over a year. This can deeply affect an individual and sometimes their relationships too. Advice is most often focused towards women, owing to the misconception that infertility is a female related medical condition. In reality, infertility affects both men and women. There are several cases of male infertility which go undiagnosed and untreated as most men are reluctant to seek help and accept that they could be the cause for failure to conceive. In fact, 45-50% of all infertility cases are attributed to the male factor either solely or combined with female factor.

Highlighting the causes of male infertility at a press meet held today, Dr Pooja Dhir Bhayana, Fertility Consultant, Nova IVF Fertility Hisar, said, “Today, male infertility has become a rising concern in Hisar with about 35-40% of cases being reported. Male infertility could be genetic, caused by an infection, testicular or pelvic injury, or a severe medical condition. Lifestyle factors such as nutrition, lack of regular exercise, work stress, exposure to environmental pollutants, etc. play a role in the development of infertility in men. Additionally, habits like cigarette smoking, illicit drug and alcohol abuse, obesity and poorly controlled diabetes can negatively impact fertility in men. Men who live a healthy lifestyle are more likely to produce healthy sperms.”

Causes of male infertility:

• Sperm disorders: Lifestyle choices, consumption of tobacco, childhood infections such as mumps and long-term diseases such as kidney failure, can damage the reproductive system and cause low or no sperm count.
• Obstruction: 4 out of every 10 men with low sperm count (azoospermia) have an obstruction (blockage). Repeated infections, surgery (such as vasectomy), swelling or developmental defects can cause blockage. With a blockage, sperm from the testicles can't leave the body during ejaculation.
• Chromosomes: Sperms carry half of the DNA to the egg. Changes in the number and structure of chromosomes can affect fertility. For example, the male Y chromosome may be missing parts.
• Varicoceles: Varicoceles are swollen veins in the scrotum. They're found in 16 out of 100 of all men. They are more common in infertile men (40 out of 100 and their presence can also impact sperm count and motility by raising the scrotal temperature and by increasing oxidative stress.
• Retrograde Ejaculation: Retrograde ejaculation is when semen goes into the bladder instead of out of the penis. This happens when nerves and muscles in your bladder don't close during orgasm.

How male infertility checkups are done

During any fertility check-up, it is mandatory to investigate both partners. A male fertility assessment usually starts with a thorough medical history, physical examination and a semen analysis that examines the count, motility and morphology of sperm in the ejaculate. Further testing is based on the results of the analysis. Men with low sperm counts, for example, might require hormonal or genetic testing. If no sperms are found in the ejaculate, a testicular biopsy may be necessary. Hormone profile, DNA fragmentation and scrotal scan with Doppler are done if abnormalities are found. Semen analysis is repeated after three months if the patient has been put on treatment.

Magnetic Activated Cell Sorting (MACS) – ART technique used in cases of male infertility

Magnetic Activated Cell Sorting is a semen preparation technique that involves the magnetic separation of healthy spermatozoa from the apoptotic ones, which have less fertility potential. The apoptosis (programmed cell death) is a regulation process of the cell cycle which may occur during spermatogenesis (the process of development of sperm cells or spermatozoa), thereby causing cell damages such as sperm DNA fragmentation. MACS helps isolate better sperms from the ones which are on the verge of death, and helps achieve better fertilisation rate, cleavage rate, implantation rate and pregnancy rate.

“The field of Assisted Reproductive Technology is rapidly progressing with many new advances since the last decade. The future of reproductive technology holds great potential to allow biological birth for those who might not otherwise have been capable of it. MACS is a safe and efficient method to select functional sperm with consistently good results. This method is highly recommended in cases with a high level of DNA fragmentation and repeated IVF failures. With advanced ART techniques like MACS, we are now able to tackle male infertility in a more efficient way”, said Dr Pooja Dhir Bayana.

Nova IVF Fertility (NIF) is among the largest service providers in the fertility space and has successfully achieved over 25,000 clinical pregnancies through IVF.

About Nova IVF Fertility

Nova IVF Fertility (NIF) is the among the largest service providers in the fertility space. NIF aims to bring advanced Assisted Reproductive Technology (ART) to India in partnership with IVF of Spain. The partnership has resulted in a substantial addition to Nova's IVF services and technology, including proprietary software, training, and quality management. With IVF's know-how and vast international expertise, NIF brings the same exceptional standard of processes, protocols, and policies to India.

In addition to providing core procedures such as IUI, IVF, and Andrology services, NIF offers several state-of-the-art technologies such as Vitrification for preserving embryos and eggs, ERA to find out the timing of the uterus' capacity to accept embryos, PGS and PGD for the transfer of genetically normal embryos – all procedures that significantly improve the chances of a pregnancy following IVF-ICSI, even in patients with multiple previous failures. NIF currently operates 20 fertility centres in India (Ahmedabad (2), Bengaluru (3), Chennai, Coimbatore, Hisar, Hyderabad, Indore, Jalandhar, Kolkata, Lucknow, Mumbai (2), New Delhi (2), Pune, Surat, and Vijayawada).

For further information, visit www.novaivifertility.com

Media contacts:

Debolina

Manager – PR, Nova IVF Fertility

Phone: +91 76194 62888

Email: debolina.mukherjee@novaivifertility.net

Nova IVF Fertility is helping patients fight infertility with advanced Assisted Reproductive Technology (ART) in Coimbatore

Infertility is a condition where a couple is unable to conceive naturally, despite having unprotected sex for more than a year. Many factors can affect conception, including the presence of sperm and egg at the right time in a receptive environment. There are several tests that can help evaluate these different aspects of fertility health. While factors such as advancing maternal age, endometriosis, ovulation disorders, sperm malfunction and other lifestyle habits are culprits for infertility, there is a hidden trouble that most have not heard of – Sexually Transmitted Diseases (or) STDs. STDs can also lead to infertility in men and women.

What is an STD?

STDs are infections transmitted through unprotected sex which may include vaginal, anal or oral intercourse. These infections also spread through sharing IV needles, breastfeeding, or giving birth. Most STDs affect both men and women, but in many cases the health problems they cause can be more severe for women. If not properly treated, an STD could lead to potential infertility issues. There are many sexually transmitted diseases that one can come in contact with; of which Chlamydia and Gonorrhea are the most common ones and can have an adverse impact on one’s fertility health.

Discussing the implications of sexually transmitted diseases on fertility at a press meet held today, Dr. Meenakshi, Fertility Consultant, Nova IVF Fertility, Coimbatore said, “Sexually transmitted infections (STI) can cause pelvic inflammatory disease (PID) in women (an infection of the uterus and fallopian tubes) and epididymitis in men (inflammation of the coiled tube beside the testes). Complications from STIs can lead to infertility or an ectopic pregnancy (an embryo that grows outside the womb). In fact, if a woman with STI is pregnant, this can also infect her baby.”

Chlamydia and infertility

Chlamydia is a sexually transmitted disease which can easily be treated with antibiotics. The effects of chlamydia on fertility are well established and apply to both men and women. Chlamydia causes a large amount of inflammation (swelling) in the fallopian tubes which tend to get blocked, restricting the travel of fertilised egg to the uterus. This condition is also known as tubal infertility. Around one in five women with Chlamydia also develop PID. Often, these infections also affect the endometrial tissue, wherein the embryo fails to get implanted, thus leading to infertility.

The symptoms of chlamydia in men are pain while urinating, discharge from the penis and pain in the testicles. Around 50% of men with chlamydia will develop symptoms within one to three weeks of contracting the disease which makes it more noticeable for men than in women. However, men who suffer from Chlamydia may find that their sperm quality and motility has significantly decreased, leading to difficulty in conceiving.

Gonorrhea and infertility

Gonorrhea is an infection caused by a sexually transmitted bacterium that can infect both males and females. Gonorrhea most often affects the urethra, rectum or throat. In females, gonorrhea can also infect the cervix. As Gonorrhea can go undetected for long periods of time, tubal damage from the disease is common. About 10% - 20 % of women with Gonorrhea have symptoms of pelvic inflammatory disease. Gonorrhea has also been shown to cause problems with sperm health in many men.

Symptoms of gonorrhoea in men include painful urination, pain or swelling in one testicle and pus-like discharge from the penis, while for women, the symptoms include increased vaginal discharge, bleeding and painful intercourse.

Elaborating on the two main pelvic infections that can lead to infertility, Dr. Meenakshi further added, “Chlamydia and Gonorrhea are the two most common and preventable infections which cause PID. If left untreated, about 10-15% of women with these infection can develop PID. Chlamydia can also cause fallopian tube infection without any symptoms. PID and “silent” infection in the upper genital tract may cause permanent damage to the fallopian tubes, uterus, and surrounding tissues which can ultimately lead to infertility.”

Diagnosis for patients with STD who are infertile:

• ALICE ( Analysis of Infectious Chronic Endometritis ) test

  In case of women, the first step of treatment includes taking the vaginal or cervical swab for culture and finding the organism involved based on which antibiotics are prescribed to reduce the infection. An endometrial tissue is also given to the laboratory to undergo the culture during a routine diagnostic laparoscopy in order to detect the exact type of infection and the type of antibiotic that can be prescribed. In case of men, discharge as well as semen is sent for culture and sensitivity to detect the organism and antibiotics are prescribed.

  The ALICE test is a microbial essay of the endometrial cavity which helps find the type of infection that is affecting the uterus and preventing the embryo from getting implanted. It also provides details on upgraded series of anti-biotics which are sensitive to the organisms. ALICE is a molecular microbiology tool used to diagnose subclinical infection of the endometrium that has been associated with infertility, especially repeated implantation failure and recurrent pregnancy loss. ALICE indicates the possible presence of bacterial pathogens, which can cause chronic endometritis or other diseases.

• STI in Male:

  For men, generally, being diagnosed with STD implies a block; sperms are formed in the epididymis and travels to a passage called the spermatic chord. In case of any infection, the chord gets affected. Over the course of its healing period, it develops a scar, which eventually, after a year or two, leads to obstructive azoospermia. Those diagnosed with this condition are advised retrieval of sperms directly from the testis or epididymis, followed by IVF.

  “Over time, we have been witnessing a rise in the cases of infertility caused due to STDs in Coimbatore. We meet several patients on a day-to-day basis who are unaware that they are suffering from obstructive azoospermia. Most of them are only prescribed antibiotics, but the right diagnosis continues to remain the need of the hour. By assessing the microbiological environment that the embryo will encounter at implantation, test methods like ALICE can be beneficial for any patient wishing to conceive”, stated Dr Meenakshi.

The earlier the STDs are diagnosed and treated, the less likely it will cause problems with fertility. Having an STD test before trying for a baby also helps reduce the risk of passing an infection to your partner or child. It is always advisable to have protected sex to avoid contact with any STDs. While the infections can be treated with antibiotics, the treatment cannot reverse scarring of the reproductive organs once it’s already occurred—and it’s the scarring that can cause infertility.

Nova IVF Fertility (NIF) is among the largest service providers in the fertility space and has successfully achieved over 25,000 clinical pregnancies through IVF.

About Nova IVF Fertility

Nova IVF Fertility (NIF) is the among the largest service providers in the fertility space. NIF aims to bring advanced Assisted Reproductive Technology (ART) to India in partnership with IVF of Spain. The partnership has resulted in a substantial addition to Nova's IVF services and technology, including proprietary software, training, and quality management. With IVF's know-how and vast international expertise, NIF brings the same exceptional standard of processes, protocols, and policies to India.

In addition to providing core procedures such as IUI, IVF, and Andrology services, NIF offers several state-of-the-art technologies such as Vitrification for preserving embryos and eggs, ERA to find out the timing of the uterus' capacity to accept embryos, PGS and PGD for the transfer of genetically normal embryos – all procedures that significantly improve the chances of a pregnancy following IVF-ICSI, even in patients with multiple previous failures. NIF currently operates 20 fertility centres in India (Ahmedabad (2), Bengaluru (3), Chennai, Coimbatore, Hisar, Hyderabad, Indore, Jalandhar, Kolkata, Lucknow, Mumbai (2), New Delhi (2), Pune, Surat, and Vijayawada).

For further information, visit www.novaivifertility.com

Media contacts:

Debolina

Manager – PR, Nova IVF Fertility

Phone: +91 76194 62888

Email: debolina.mukherjee@novaivifertility.net